HistaEze is a synergistic blend of nutrients that provides natural support to help balance the immune response during allergy season. It features Tinofend, a patented and clinically researched extract derived from the plant Tinospora cordifolia, which has been shown to regulate key immune mediators and support the activity of macrophages. Tinofend supports the immune response by promoting a balance of phagocytic white blood cells and eosinophils. HistaEze also contains quercetin, nettle leaf and vitamin C, all of which have long histories of use in helping to support immune balance during the allergy season. Additionally, bicarbonate salts are included for their role in maintaining normal histamine metabolism. Made with non-GMO ingredients.